An independent guide
Where the medicine is legal,
and who can be trusted.
Ayahuasca, psilocybin, iboga and San Pedro: the jurisdictions where each is lawful, the screening that keeps people safe, and the research worth reading. Written for people making a real decision, not browsing.
123 listed centres · 25 guides · No sourcing, ever
The directory, by jurisdiction
- 6 centres
Jamaica
Legal · Psilocybin
- 8 centres
Netherlands
Legal · Psilocybin (truffles)
- 21 centres
Oregon, USA
Licensed · Psilocybin
- 46 centres
Colorado, USA
Licensed · Psilocybin
- 13 centres
Peru
Legal · Ayahuasca
- 13 centres
Costa Rica
Tolerated · Ayahuasca
- 4 centres
Brazil
Tolerated · Ayahuasca
- 12 centres
Mexico
Unregulated · Ibogaine
Jurisdictions
Legal status, country by country
Psilocybin is licensed in Oregon, legal in Jamaica, decriminalised in Portugal and prosecuted in Norway. The map is not intuitive and it moves. Check before you travel, not after.
Read moreHarm reduction
The screening nobody does
SSRIs with an MAOI brew. A family history of psychosis. An undiagnosed heart condition before ibogaine. Most serious incidents trace back to a question that was never asked.
Read moreEvidence
What the trials found
Peer-reviewed studies, summarised without the press-release gloss, including the ones with null results, small samples and unblinded designs.
Read moreOur position
We don't list peyote ceremonies.
Peyote is a slow-growing cactus under real pressure in the wild, and it is the sacrament of the Native American Church, whose leadership has asked, repeatedly, that it not be opened to the wider market.
That position is not fringe. When Colorado decriminalised mescaline under the Natural Medicine Health Act, it deliberately excluded Lophophora williamsii at the request of the National Council of Native American Churches and the Indigenous Peyote Conservation Initiative.
So we point that demand where it belongs: San Pedro, the same primary alkaloid from a fast-growing cactus that can be cultivated legally in much of the world.
The library
Start here
Psilocybin Clinical Trial Results: What the Latest Research Shows
Major clinical trials at Johns Hopkins, NYU, and Imperial College London have produced groundbreaking results for psilocybin therapy. Here is what the data actually shows across depression, anxiety, and addiction studies.
6 min read
MDMA Therapy for PTSD: How It Works and What Studies Reveal
MDMA-assisted therapy has shown unprecedented success rates in treating PTSD. We examine the therapeutic protocol, Phase III trial results, and the path toward potential FDA approval.
6 min read
Psychedelic Safety Checklist: Before, During, and After
A comprehensive safety checklist covering medical screening, preparation, in-session protocols, and post-experience care. Print this out and review it before any psychedelic experience.
6 min read
- Peyote: Cultural Significance and Sacred Traditions
- Harm Reduction Basics: A Practical Guide to Safer Use
- Set and Setting: The Most Important Variables in a Psychedelic Experience
- Integration Practices: Making Sense of Psychedelic Experiences
- Legal Status of Psychedelics by Country: 2026 Overview
- Microdosing Research Review: What Science Actually Shows
The directory
Where it is legal
123 centres across 8 jurisdictions where the medicine they serve is lawful, state-licensed or unregulated, or tolerated though not authorised (Costa Rica and Brazil). Nothing operating underground is listed here, and a listing isn't an endorsement, so every profile says plainly what we have and haven't checked, and shows any public record.
Jamaica
Psilocybin
Psilocybin mushrooms are not listed in Jamaica's Dangerous Drugs Act: unscheduled and unregulated, with no licensing regime.
6 centres
Netherlands
Psilocybin (truffles)
Fresh psilocybin truffles (sclerotia) are outside the Opium Act; mushrooms, fresh or dried, have been banned since December 2008.
8 centres
Oregon, USA
Psilocybin
State-licensed psilocybin services under ORS 475A (Measure 109), for adults 21 and over.
21 centres
Colorado, USA
Psilocybin
Licensed healing centres under the Natural Medicine Health Act, for adults 21 and over.
46 centres
Peru
Ayahuasca
Traditional ayahuasca use is protected as national cultural heritage; there is no licensing regime for retreats.
13 centres
Costa Rica
Ayahuasca
Ayahuasca is not named in Costa Rica's drug law but is not authorised either: tolerated in practice, and the subject of a January 2025 Health Ministry warning.
13 centres
Brazil
Ayahuasca
Religious use of ayahuasca is permitted; paid retreats for visitors sit in a legal grey area under CONAD Resolution 1/2010.
4 centres
Mexico
Ibogaine
Ibogaine is not listed in Mexico's General Health Law: unregulated, not approved.
12 centres
Without a psychedelic
For everyone the screening rules out
A psychosis history, a cardiac condition, an SSRI prescription, or no money this year. Plenty of people arrive here and find the answer is no. 15 practices and 43 named centres that reach comparable territory without a controlled substance, and some of them are harder than anything in the directory above.