Psilocybin retreats in Colorado

46 psilocybin centres in Colorado, listed because psilocybin is licensed there. Every licensed centre on the state register is listed except those it shows as closed, withdrawn or surrendered. Nothing operating underground is listed.

Is psilocybin legal in Colorado?

Licensed · Psilocybin

Licensed healing centres under the Natural Medicine Health Act, for adults 21 and over.

Colorado's Natural Medicine Health Act (Proposition 122, 2022), as amended by SB23-290, lets the Department of Revenue's Natural Medicine Division license healing centres, with facilitators licensed separately. The division issued its first healing centre licence on 31 March 2025. Natural medicine currently means psilocybin and psilocyn, and the statute excludes peyote by name. Psilocybin remains a Schedule I substance under federal law.

What the sources say

Voters approved Proposition 122, the Natural Medicine Health Act, in November 2022. It added Article 170 to Title 12 of the Colorado Revised Statutes. (Colorado Secretary of State, 2022; Colorado Lawyer (Colorado Bar Association))
SB23-290 (Natural Medicine Regulation and Legalization) was signed on 23 May 2023. It amends C.R.S. 12-170 (facilitators, regulated by the Department of Regulatory Agencies, Division of Professions and Occupations) and creates C.R.S. 44-50 (natural medicine businesses, regulated by the Department of Revenue Natural Medicine Division). (Colorado General Assembly, 23 May 2023; Colorado General Assembly, 23 May 2023; Colorado Lawyer (Colorado Bar Association))
'Natural medicine' means psilocybin and psilocyn. DMT and mescaline may be added only if the advisory board recommends it and regulators approve, on or after 1 June 2026. Ibogaine may be added by the same process (C.R.S. 12-170-104(12) and 44-50-103). (Colorado General Assembly, 23 May 2023)
Peyote is excluded by statute: "'Mescaline' does not include peyote, meaning all parts of the plant classified botanically as Lophophora williamsii Lemaire, whether growing or not; its seeds; any extract from any part of the plant, and every compound, salt, derivative, mixture, or preparation of the plant; or its seeds or extracts." (C.R.S. 12-170-104 and 44-50-103, as enacted by SB23-290). (Colorado General Assembly, 23 May 2023)
Facilitators and participants must be 21 or older: SB23-290 defines both as individuals who are twenty-one years of age or older. (Colorado General Assembly, 23 May 2023)
The Natural Medicine Division began granting licences on or before 31 December 2024, as the statute required. It issued Colorado's first healing center licence to The Center Origin on 31 March 2025, and noted that operations also depend on local approvals and on licensed cultivation and testing. (Colorado General Assembly, 23 May 2023; Colorado Department of Revenue, Natural Medicine Division, 2 Apr 2025)
Psilocybin, psilocyn, DMT, mescaline, peyote and ibogaine are all Schedule I under 21 USC 812. (Legal Information Institute (Cornell) reproducing the U.S. Code, current text)

Source: Colorado Natural Medicine Division Licensee Look-up Tool (facility search, licence type 'NM Healing Center'), Colorado Department of Revenue, Natural Medicine Division (NMD), read 28 Sep 2026. The state look-up gives the licensed entity, licence number, status, city and expiry. Trade names, tier, addresses and websites come from the Natural Medicine Division's self-reported healing centre directory, matched to the licence by name. Centres the register shows as closed, withdrawn or surrendered are not listed. A state licence is not an audit.

More jurisdictions and substances in the legal status table.

What a licensed session involves

PreparationA required session of roughly two hours with your licensed facilitator, often available over video. Intentions, history, expectations, and what will happen on the day.
Administration6 to 8 hours at a licensed service centre, with a facilitator present the whole time. State rules set a minimum stay based on dose. You cannot take the product away.
IntegrationThe facilitator follows up within 72 hours, with an integration session of about two hours offered.
PracticalitiesPlan 3 to 5 days near the centre: a day or two before to prepare, and a day or two after before travelling. No prescription or diagnosis is required, and no medical referral.

The general shape of licensed services. These centres do not publish programme prices on the register, so none are shown; ask each centre for a written quote.

What to check before booking

Oregon's rules set some medical exclusions in law; these are the sourced ones, and the questions any licensed centre should ask you.

Lithium: seizure riskSerious risk
An analysis of online reports found that 47% of 62 reports of lithium taken with a classic psychedelic (such as psilocybin or LSD) involved seizures and 39% involved medical attention, while none of 34 lamotrigine reports did. The authors provisionally concluded psychedelic use may pose a significant seizure risk for people on lithium. (Pharmacopsychiatry, 2021)
Oregon bars recent lithium usersSerious risk
Oregon's required Client Information Form asks whether the client has taken lithium in the last 30 days; a yes answer means the client may not participate in an administration session. (Oregon Health Authority, Public Health Division, 2026)
Psychosis and severe psychiatric historySerious risk
Published research safety guidelines recommend excluding volunteers with a personal or family history of psychotic disorders or other severe psychiatric disorders, and note prolonged psychoses triggered by hallucinogens are less common than acute distress. Oregon's Client Information Form bars anyone who has ever been diagnosed with or treated for active psychosis. (Journal of Psychopharmacology, 2008; Oregon Health Authority, Public Health Division, 2026)
Bipolar disorderSerious risk
In an international survey of 541 people with self-reported bipolar disorder who had used psilocybin, 32.2% described new or increasing symptoms after trips, prominently manic symptoms, sleep problems and anxiety; 3.3% used emergency medical services. The authors say bipolar symptoms may emerge or intensify after psilocybin use. (Journal of Psychopharmacology, 2023)
Tricyclic antidepressants and lithium may intensify effectsWorth knowing
A small retrospective questionnaire study (10 people using LSD, not psilocybin) found chronic tricyclic antidepressant or lithium use was associated with subjectively stronger physical, hallucinatory and psychological responses, while chronic MAOI use was associated with weaker responses. (Behavioural Brain Research, 1996)
Blood pressure and heart rateWorth knowing
NIDA states that psilocybin typically raises blood pressure and heart rate, which may be dangerous for people with heart conditions. A 2024 meta-analysis of psychedelic trials found an increased risk of elevated heart rate and systolic and diastolic blood pressure at all dose ranges during the acute phase. (National Institute on Drug Abuse (NIH); Psychiatry Research, 2024; EMCDDA (now EUDA), via Internet Archive snapshot 2024-06-18)
Oregon's mandatory client screening questionsWorth knowing
Before any Oregon administration session, the client must complete a Client Information Form with a facilitator, answering yes/no questions on lithium use, current treatment for medical or mental health conditions, mushroom allergy, medications, thoughts or history of harming self or others, active psychosis and pregnancy or breastfeeding. Current thoughts of harming self or others, lithium in the last 30 days, or a history of active psychosis rule out a session; clients who are pregnant or breastfeeding must be told the risks are unknown. (Oregon Health Authority, Public Health Division, 2026)

Every cited psilocybin safety fact

Questions this data answers

Legal psilocybin in the US: the licensed centres in Oregon and Colorado

Other locations