Lawful routes
Psychedelic and ketamine clinical trials recruiting now
203 trials registered on ClinicalTrials.gov were recruiting on 26 Oct 2026, 119 of them with sites in the United States. By substance: Psilocybin 102, Ketamine / esketamine 72, MDMA 23, DMT / ayahuasca 11, LSD 6, 5-MeO-DMT 1.
Psilocybin, DMT and ibogaine are Schedule I under federal law, so outside Oregon's and Colorado's licensed psilocybin programmes a registered trial is one of the few lawful ways to receive them in the US. (Legal Information Institute (Cornell) reproducing the U.S. Code, current)
From the ClinicalTrials.gov registry (US National Library of Medicine), read through its public API on 26 Oct 2026: studies marked as recruiting whose interventions name the substance. Titles, sponsors, phases, conditions and sites are the registry's own entries, written by the sponsors. We have not vetted any trial, and recruiting status changes; the registry record and the study team have the current eligibility rules.
By condition
- Depression86 trials, 49 in the US
- PTSD29 trials, 21 in the US
- Alcohol use disorder12 trials, 5 in the US
- Opioid use disorder14 trials, 11 in the US
- Anxiety13 trials, 9 in the US
- Cancer and end-of-life distress14 trials, 8 in the US
- Eating disorders3 trials, 2 in the US
- OCD8 trials, 6 in the US
- Bipolar disorder6 trials, 3 in the US
Too few for their own page (under 3): smoking and nicotine (2), cocaine and methamphetamine (2), gambling (1). They are listed on the condition and state pages they belong to.
By US state
- Maryland22
- New York18
- California17
- Connecticut14
- Texas11
- Georgia8
- Massachusetts7
- Pennsylvania5
- Alabama4
- Colorado4
- Tennessee4
- Washington4
- Illinois3
- Iowa3
- Minnesota3
- New Mexico3
- Ohio3
- Rhode Island3
- Wisconsin3
States with at least 3 recruiting trials at an open site. Trials in other states are on the condition pages.
How taking part works
- ClinicalTrials.gov, run by the US National Library of Medicine, lists studies using information supplied by each study's sponsor or investigator. Listing a study does not mean it has been evaluated by the US federal government, and the NLM advises talking to your health care provider about the risks and potential benefits before taking part. (U.S. National Library of Medicine (NIH), Oct 2023)
- The National Institute on Aging's list of questions to ask before joining a trial includes whether it will cost anything to take part, whether expenses such as travel, parking, lodging or meals are reimbursed, and whether your insurance will pay for costs the research does not cover. Ask the study team; the answer varies by study. (National Institute on Aging (NIH), current page)