The library
Guides
25 pieces on what the research shows, how people stay safe, where the law stands, and what happens after the experience.
Psilocybin Clinical Trial Results: What the Latest Research Shows
Major clinical trials at Johns Hopkins, NYU, and Imperial College London have produced groundbreaking results for psilocybin therapy. Here is what the data actually shows across depression, anxiety, and addiction studies.
6 min read
MDMA Therapy for PTSD: How It Works and What Studies Reveal
MDMA-assisted therapy has shown unprecedented success rates in treating PTSD. We examine the therapeutic protocol, Phase III trial results, and the path toward potential FDA approval.
ReadCulture & historyPeyote: Cultural Significance and Sacred Traditions
Peyote has been used ceremonially by Indigenous peoples for thousands of years. Understanding its cultural context is essential before discussing its pharmacology or legal status.
ReadHarm reductionHarm Reduction Basics: A Practical Guide to Safer Use
Harm reduction accepts that psychedelic use occurs and focuses on minimizing risks. This guide covers testing, dosing, environment, and emergency protocols.
ReadHarm reductionSet and Setting: The Most Important Variables in a Psychedelic Experience
The concepts of set and setting were formalized by Timothy Leary in the 1960s but have roots in Indigenous practices going back millennia. Here is how to optimize both for safer, more meaningful experiences.
ReadTherapy & integrationIntegration Practices: Making Sense of Psychedelic Experiences
The psychedelic experience itself is only the beginning. Integration is the process of making sense of and applying insights from altered states into everyday life. Without it, even profound experiences can fade without lasting impact.
ReadLegalLegal Status of Psychedelics by Country: 2026 Overview
Psychedelic laws vary dramatically around the world, from full criminalization to regulated medical access. This overview covers the current legal landscape across major jurisdictions.
ReadResearchMicrodosing Research Review: What Science Actually Shows
Microdosing psychedelics has become a mainstream wellness trend, but does the controlled research support the claims? We review the published clinical evidence and its limitations.
ReadTherapy & integrationPsychedelic-Assisted Therapy: A Comprehensive Overview
Psychedelic-assisted therapy combines carefully administered psychedelic substances with professional psychological support. This overview covers how it works, what conditions it treats, and what to expect.
ReadResearchDMT and the Brain: What Neuroscience Reveals
DMT is one of the most potent and mysterious psychedelics known to science. Recent brain imaging studies and the discovery of endogenous DMT have opened new frontiers in neuroscience research.
ReadCulture & historyLSD: History, Science, and Modern Research
From Albert Hofmann's accidental discovery to modern neuroscience labs, LSD has had one of the most remarkable journeys in pharmacological history. This article traces its path from lab to culture to clinical research.
ReadTherapy & integrationKetamine Therapy for Depression: What You Need to Know
Ketamine is the only psychedelic-adjacent substance currently available by prescription for depression. Here is how it works, what the evidence shows, and how treatment is typically administered.
ReadResearchIbogaine for Addiction Treatment: Promise and Risk
Ibogaine has shown remarkable potential for interrupting opioid addiction, but it carries serious cardiac risks. This article examines the evidence, the dangers, and the current state of ibogaine treatment.
ReadHarm reductionPsychedelic Safety Checklist: Before, During, and After
A comprehensive safety checklist covering medical screening, preparation, in-session protocols, and post-experience care. Print this out and review it before any psychedelic experience.
ReadHarm reductionDrug Interaction Warnings: Psychedelics and Medications
Combining psychedelics with certain medications can be dangerous or fatal. This guide covers the most critical interactions, including SSRIs, MAOIs, lithium, and stimulants.
ReadHarm reductionThe Trip Sitter's Guide: How to Support Someone Safely
Being a trip sitter is a responsibility that can make the difference between a meaningful experience and a traumatic one. Here is how to provide effective, compassionate support.
ReadCulture & historyThe Psychedelic Renaissance: A Timeline of Key Milestones
From the founding of MAPS in 1986 to Oregon's psilocybin program and Australia's rescheduling, the psychedelic renaissance has unfolded over four decades. Here are the pivotal moments.
ReadCulture & historyIndigenous Use and Cultural Respect: An Ethical Framework
Psychedelic use has deep Indigenous roots across every continent. As Western interest surges, questions of cultural appropriation, conservation, and reciprocity demand thoughtful engagement.
ReadLegalDecriminalization vs Legalization: Understanding the Difference
These terms are often used interchangeably but mean very different things in practice. Understanding the distinction is essential for informed participation in the psychedelic policy debate.
ReadResearchPsychedelic Research Institutions: Who Is Doing the Work
From Johns Hopkins to Imperial College, a growing number of prestigious institutions are conducting psychedelic research. Here is a guide to the major centers and what they are studying.
ReadHarm reductionHow to Prepare for a Psychedelic Experience
Proper preparation can be the difference between a transformative experience and a distressing one. This guide covers physical, psychological, and logistical preparation in detail.
ReadHarm reductionChallenging Psychedelic Experiences and How to Handle Them
Difficult psychedelic experiences are not uncommon and can be profoundly meaningful if handled correctly. Understanding what causes them and how to navigate them transforms fear into preparedness.
ReadResearchNeuroplasticity and Psychedelics: How They Rewire the Brain
Psychedelics promote neuroplasticity by increasing dendritic spine growth, BDNF expression, and cross-network connectivity. These mechanisms may explain their rapid and durable therapeutic effects.
ReadResearchPsychedelics and Creativity: What the Research Shows
The link between psychedelics and creativity is one of the oldest claims in psychedelic culture. Modern neuroscience is beginning to explain why some people report creative breakthroughs, and where the evidence stands.
ReadResearchThe Future of Psychedelic Medicine: What to Expect
Psychedelic medicine is at an inflection point. From FDA approvals to AI-guided therapy sessions, the next decade will shape how these substances integrate into mainstream healthcare.
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