Other
12-methoxyibogamine
Sacred to the Bwiti religion in West Africa, used in initiation ceremonies and spiritual healing for centuries.
At a glance
Reported effects
Legal status
Unscheduled in most countries but regulated. Legal ibogaine clinics exist in some nations.
Research
Clinical trials for addiction treatment, particularly opioid addiction.
Cherian KN, et al. · Nature Medicine · 2024
Open-label study of 30 veterans with brain injury: magnesium-ibogaine was followed by large drops in disability, PTSD, depression and anxiety at 1 month.
What the study foundKnuijver T, et al. · Addiction · 2022
Hospital study in 14 opioid-dependent patients: one ibogaine dose lengthened QTc by 95 ms on average; half passed 500 ms.
What the study foundBrown TK, et al. · American Journal of Drug and Alcohol Abuse · 2018
Observational study of 30 people with opioid dependence: after ibogaine detox, half reported no opioid use at 1 month; gains partly faded.
What the study foundNoller GE, et al. · The American Journal of Drug and Alcohol Abuse · 2018
Small New Zealand follow-up of 14 people found less opioid use and depression a year after one ibogaine treatment; one participant died.
What the study foundBrown TK · Current Drug Abuse Reviews · 2013
Review of ibogaine for addiction: animal research supports reduced withdrawal and craving, but safety concerns and scarce human data remain.
What the study foundAlper KR, et al. · Journal of Forensic Sciences · 2012
Review of 19 deaths after ibogaine (1990 to 2008): most involved heart disease or other drugs; withdrawal seizures also a risk.
What the study foundGlick SD, et al. · Brain Research · 1994
Rat study found ibogaine and related alkaloids reduced morphine and cocaine self-administration, sometimes for several days after one dose.
What the study foundThe dispatch
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