Clinical trials / PTSD

Recruiting psychedelic and ketamine trials for PTSD

29 trials registered on ClinicalTrials.gov were recruiting on 26 Oct 2026, 21 of them at sites in the United States (17 states). By substance: MDMA 12, Psilocybin 10, Ketamine / esketamine 8, DMT / ayahuasca 1.

What the published research shows so far: MDMA-assisted therapy for PTSD: the evidence and the FDA decision

From the ClinicalTrials.gov registry (US National Library of Medicine), read through its public API on 26 Oct 2026: studies marked as recruiting whose interventions name the substance. Titles, sponsors, phases, conditions and sites are the registry's own entries, written by the sponsors. We have not vetted any trial, and recruiting status changes; the registry record and the study team have the current eligibility rules.

Trials with US sites

Phase 2/3PsilocybinNCT07570654
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder (Redefine)
Conditions:
PTSD - Post Traumatic Stress Disorder; PTSD; PTSD Symptoms; PTSD, Post Traumatic Stress Disorder
Sponsor:
COMPASS Pathways
Who:
ages 18 Years and over, 300 participants planned
Also in:
Canada
- AZ, Tucson, Arizona
- FL, Miami, Florida
- FL, Orlando, Florida
- IL, Chicago, Illinois
- MN, Eden Prairie, Minnesota
- NE, Lincoln, Nebraska
- and 3 more US sites on the registry record
Phase 2MDMANCT05790239
MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder
Conditions:
Post Traumatic Stress Disorder
Sponsor:
Stephen Robert Marder
Who:
ages 18 Years and over, 40 participants planned
- VA Greater Los Angeles Healthcare System, Westwood campus, Los Angeles, California (not yet recruiting)
- West Los Angeles Veteran Affairs, Los Angeles, California
ObservationalKetamine / esketamineNCT06070766
RIVER At Home Ketamine Protocols
Conditions:
Chronic Condition; Chronic Pain; Chronic Disease; Major Depressive Disorder; Post Traumatic Stress Disorder; Anxiety Disorders
Sponsor:
RIVER Foundation
Who:
ages 18 Years and over, 50000 participants planned
- RIVER Foundation, Bigfork, Montana
- RIVER Telehealth, Helena, Montana
Phase 4Ketamine / esketamineNCT06903819
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
Conditions:
Orthopedic Trauma Surgery Patients; Postoperative Pain; Opioid Use; Depression; Post-traumatic Stress Disorder (PTSD)
Sponsor:
Texas Tech University Health Sciences Center
Who:
ages 18 Years to 65 Years, 90 participants planned
- Texas Tech University Health Sciences Center Lubbock, Lubbock, Texas
- University Medical Center, Lubbock, Texas
Phase 2/3MDMANCT07118839
MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder (MAP VETS)
Conditions:
Post Traumatic Stress Disorder; Alcohol Use Disorder
Sponsor:
VA Office of Research and Development
Who:
ages 18 Years and over, 80 participants planned
- VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut
- Providence VA Medical Center, Providence, RI, Providence, Rhode Island
Phase 2MDMANCT05219175
MDMA for Co-occurring PTSD and OUD After Childbirth
Conditions:
Stress Disorders, Post-Traumatic; Opioid Use Disorder
Sponsor:
University of New Mexico
Who:
ages 18 Years and over, 15 participants planned
- University of New Mexico Health Sciences, Albuquerque, New Mexico
Phase 2Ketamine / esketamineNCT05786066
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Conditions:
Depressive Disorder; Major Depressive Disorder; Bipolar Disorder; Post Traumatic Stress Disorder; Suicidal Ideation
Sponsor:
Yale University
Who:
ages 21 Years to 65 Years, 30 participants planned
- VA Connecticut Healthcare System, West Haven, Connecticut
Phase 2MDMANCT05837845
MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress Disorder
Conditions:
PTSD
Sponsor:
Patricia Suppes
Who:
ages 18 Years and over, 30 participants planned
- VA Palo Alto Health Care System / Stanford University, Palo Alto, California
Phase 1Ketamine / esketamineNCT05915013
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
Conditions:
Depressive Disorder, Major; Post Traumatic Stress Disorder
Sponsor:
Yale University
Who:
ages 18 Years to 60 Years, 50 participants planned
- Yale University, New Haven, Connecticut
Phase 4Ketamine / esketamineNCT06414356
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
Conditions:
Neuropathic Pain; PTSD
Sponsor:
Margaux M. Salas, PhD
Who:
ages 18 Years to 70 Years, 30 participants planned, accepts healthy volunteers
- Brooke Army Medical Center, San Antonio, Texas
Phase 2MDMANCT06418178
Dose Optimization of MDMA-Assisted Therapy for PTSD (DosOp)
Conditions:
Posttraumatic Stress Disorder
Sponsor:
Bronx VA Medical Center
Who:
ages 18 Years and over, 60 participants planned
- James J. Peters VA Medical Center, The Bronx, New York
Phase 1PsilocybinNCT06442423
Open-Label Psilocybin Study in Transdiagnostic Population
Conditions:
Transdiagnostic; Depression - Major Depressive Disorder; Anxiety; PTSD Symptoms; PTSD; Substance Use; Substance Use Disorder (SUD); OCD
Sponsor:
Yale University
Who:
ages 18 Years and over, 50 participants planned, accepts healthy volunteers
- Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut
Phase 2PsilocybinNCT06888128
State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma (STARLIGHT)
Conditions:
PTSD
Sponsor:
Baylor College of Medicine
Who:
ages 21 Years to 64 Years, 15 participants planned
- Baylor College of Medicine, Houston, Texas
Phase 2PsilocybinNCT06902974
Psilocybin-Assisted Therapy for Sexual Assault-Related PTSD (SUN004)
Conditions:
Post Traumatic Stress Disorder; PTSD
Sponsor:
Sunstone Medical
Who:
ages 18 Years and over, 70 participants planned
- Sunstone Medical, PC, Rockville, Maryland
Phase 1Psilocybin, MDMANCT06989957
Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD) (PAM-VET)
Conditions:
Posttraumatic Stress Disorder
Sponsor:
Johns Hopkins University
Who:
ages 21 Years and over, 40 participants planned
- Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
Phase 2PsilocybinNCT07104916
Mindfulness-based Psilocybin Therapy for PTSD
Conditions:
Post Traumatic Stress Disorder; Depression - Major Depressive Disorder
Sponsor:
Anthony P King
Who:
ages 21 Years to 65 Years, 30 participants planned
- The Ohio State University Medical Center, Columbus, Ohio
Phase 2MDMANCT07288151
MDMA-Assisted Massed Exposure Therapy for PTSD
Conditions:
Post Traumatic Stress Disorder
Sponsor:
Emory University
Who:
ages 21 Years to 70 Years, 200 participants planned
- Emory Brain Health Center, Atlanta, Georgia
Phase 2PsilocybinNCT07332143
Psilocybin-Assisted Therapy
Conditions:
PTSD
Sponsor:
Emory University
Who:
ages 18 Years and over, 150 participants planned
- Emory University Hospital, Atlanta, Georgia
Phase 1PsilocybinNCT07506395
Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder (GPAT)
Conditions:
PTSD
Sponsor:
University of New Mexico
Who:
ages 18 Years to 89 Years, 36 participants planned
- Interdisciplinary Substance Use and Brain Injury (ISUBI), Albuquerque, New Mexico
Phase 2Ketamine / esketamineNCT07563296
KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn Injury (KALM-B)
Conditions:
PTSD and Trauma-related Symptoms
Sponsor:
Irma Fleming
Who:
ages 18 Years to 65 Years, 12 participants planned
- University of Utah Health, Salt Lake City, Utah
Phase 2MDMANCT07569159
MDMA Therapy in Veterans With PTSD
Conditions:
Post Traumatic Stress Disorder
Sponsor:
Sunstone Medical
Who:
ages 18 Years and over, 52 participants planned
- Sunstone Therapies, Rockville, Maryland

Trials outside the United States

Phase 2MDMANCT05732155
Preliminary Effectiveness of Hybrid Individual and Group MDMA-assisted Therapy for War-related PTSD
Conditions:
Post Traumatic Stress Disorder; MDMA ('Ecstasy')
Sponsor:
Guy Schusheim
Who:
ages 18 Years and over, 60 participants planned
Where:
Israel
Phase 2MDMANCT06044675
MDMA-Assisted CBCT for PTSD vs CBCT RCT
Conditions:
Post Traumatic Stress Disorder
Sponsor:
Remedy
Who:
ages 18 Years to 80 Years, 60 participants planned, accepts healthy volunteers
Where:
Canada
Phase 3MDMANCT06394284
Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational and Hyperarousal-Related Neural Reactivity Mechanisms in Veterans With PTSD and Moral Injury
Conditions:
PTSD, Post Traumatic Stress Disorder; Moral Injury
Sponsor:
Herzog Hospital
Who:
60 participants planned
Where:
Israel
Phase 1/2Ketamine / esketamineNCT07009158
Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSD
Conditions:
Chronic Pain; Posttraumatic Stress Disorder (PTSD)
Sponsor:
Dr. Yuliya Knyahnytska
Who:
ages 18 Years to 64 Years, 30 participants planned
Where:
Canada
Phase 2Ketamine / esketamine, DMT / ayahuascaNCT07317206
Ayahuasca, Esketamine and PTSD
Conditions:
Posttraumatic Stress Disorder (PTSD)
Sponsor:
University of Sao Paulo
Who:
ages 18 Years to 65 Years, 10 participants planned
Where:
Brazil
Phase 2MDMANCT07469098
Group vs Individual MDMA-Assisted Therapy for PTSD After the October 7, 2023 Events
Conditions:
PTSD
Sponsor:
Sheba Medical Center
Who:
ages 18 Years to 75 Years, 168 participants planned
Where:
Israel
Phase 3PsilocybinNCT07703722
Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder
Conditions:
Major Depressive Disorder; Post-Traumatic Stress Disorder (PTSD)
Sponsor:
Khyber Medical University Peshawar
Who:
ages 18 Years to 60 Years, 60 participants planned
Where:
Pakistan
Early phase 1PsilocybinNCT07737054
Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for PTSD (TiPAP-PTSD)
Conditions:
Post-Traumatic Stress Disorder, PTSD
Sponsor:
Tel-Aviv Sourasky Medical Center
Who:
ages 21 Years to 65 Years, 13 participants planned
Where:
Israel

Recruiting psychedelic and ketamine trials for PTSD

Trials with US sites

Trials outside the United States

Laws change. Centres change. Know before you book.