Clinical trials / Pennsylvania
Psychedelic and ketamine trials recruiting in Pennsylvania
5 trials registered on ClinicalTrials.gov were recruiting at one or more sites in Pennsylvania on 26 Oct 2026. By substance: Psilocybin 3, Ketamine / esketamine 2. By condition: depression 3, opioid use disorder 2, anxiety 1, ocd 1.
From the ClinicalTrials.gov registry (US National Library of Medicine), read through its public API on 26 Oct 2026: studies marked as recruiting whose interventions name the substance. Titles, sponsors, phases, conditions and sites are the registry's own entries, written by the sponsors. We have not vetted any trial, and recruiting status changes; the registry record and the study team have the current eligibility rules.
Phase 3PsilocybinNCT07226232
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression (PIVOT)
- Conditions:
- Major Depression
- Sponsor:
- VA Office of Research and Development
- Who:
- ages 18 Years to 75 Years, 240 participants planned
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia, Pennsylvania
Phase 2PsilocybinNCT06786325
Wellcome Leap Psilocybin for OUD
- Conditions:
- Opioid Use Disorder
- Sponsor:
- Anna Rose Childress, Ph.D.
- Who:
- ages 18 Years to 60 Years, 36 participants planned
- University of Pennsylvania, Philadelphia, Pennsylvania
Early phase 1Ketamine / esketamineNCT06788249
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine
- Conditions:
- Major Depressive Disorder (MDD)
- Sponsor:
- University of Pennsylvania
- Who:
- ages 25 Years to 65 Years, 10 participants planned
- University of Pennsylvania, Philadelphia, Pennsylvania
Phase 2PsilocybinNCT06810310
Psilocybin on Brain Mechanisms of Motivation in OUD
- Conditions:
- Opioid Use Disorder
- Sponsor:
- University of Pennsylvania
- Who:
- ages 18 Years to 60 Years, 24 participants planned
- University of Pennsylvania, Philadelphia, Pennsylvania
ObservationalKetamine / esketamineNCT06997549
Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments
- Conditions:
- Depression; OCD; Anxiety Depression
- Sponsor:
- Neuronetics
- Who:
- ages 5 Years to 100 Years, 12000 participants planned
- Neuronetics, Malvern, Pennsylvania