Clinical trials / Opioid use disorder
Recruiting psychedelic and ketamine trials for opioid use disorder
14 trials registered on ClinicalTrials.gov were recruiting on 26 Oct 2026, 11 of them at sites in the United States (9 states). By substance: Psilocybin 8, Ketamine / esketamine 5, MDMA 1.
What the published research shows so far: Ibogaine for opioid addiction: the evidence and the cardiac risk
From the ClinicalTrials.gov registry (US National Library of Medicine), read through its public API on 26 Oct 2026: studies marked as recruiting whose interventions name the substance. Titles, sponsors, phases, conditions and sites are the registry's own entries, written by the sponsors. We have not vetted any trial, and recruiting status changes; the registry record and the study team have the current eligibility rules.
Trials with US sites
Phase 2PsilocybinNCT06796062
Psilocybin for Opioid Use Disorder (OUD)
- Conditions:
- Opioid Use Disorder
- Sponsor:
- NYU Langone Health
- Who:
- ages 18 Years to 65 Years, 480 participants planned
- Duke City Recovery Toolbox, Albuquerque, New Mexico
- University of New Mexico, Albuquerque, New Mexico
- StartCare, Brooklyn, New York
- NYU Langone Health, New York, New York
- VIP Community Services, Inc, The Bronx, New York
Phase 4Ketamine / esketamineNCT06903819
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
- Conditions:
- Orthopedic Trauma Surgery Patients; Postoperative Pain; Opioid Use; Depression; Post-traumatic Stress Disorder (PTSD)
- Sponsor:
- Texas Tech University Health Sciences Center
- Who:
- ages 18 Years to 65 Years, 90 participants planned
Phase 1PsilocybinNCT04161066
Adjunctive Effects of Psilocybin and a Formulation of Buprenorphine
- Conditions:
- Opioid Use Disorder
- Sponsor:
- University of Wisconsin, Madison
- Who:
- ages 21 Years to 65 Years, 10 participants planned
- University of Wisconsin, Madison, Wisconsin
Phase 2MDMANCT05219175
MDMA for Co-occurring PTSD and OUD After Childbirth
- Conditions:
- Stress Disorders, Post-Traumatic; Opioid Use Disorder
- Sponsor:
- University of New Mexico
- Who:
- ages 18 Years and over, 15 participants planned
- University of New Mexico Health Sciences, Albuquerque, New Mexico
Phase 2PsilocybinNCT06001749
Psilocybin in Cancer Pain Study
- Conditions:
- Opioid-Related Disorders; Pain Management; Pain Management and Care; Advanced Cancer; Advanced Cancers
- Sponsor:
- Yvan Beaussant, MD, MSci
- Who:
- ages 18 Years and over, 15 participants planned
- Dana-Farber Cancer Institute, Boston, Massachusetts
Phase 2PsilocybinNCT06067737
Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder (BIPOD-Out)
- Conditions:
- Opioid Use Disorder
- Sponsor:
- Johns Hopkins University
- Who:
- ages 21 Years to 70 Years, 90 participants planned
- Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
Phase 1PsilocybinNCT06160284
Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)
- Conditions:
- Opioid Use Disorder
- Sponsor:
- Yale University
- Who:
- ages 25 Years to 55 Years, 12 participants planned
- Yale University, New Haven, Connecticut
Phase 4Ketamine / esketamineNCT06506565
Low-Dose Ketamine Infusion During Burn Wound Care (IMPROVE)
- Conditions:
- Burn; Pain; Dissociation; Opioid
- Sponsor:
- University of Tennessee
- Who:
- ages 18 Years and over, 140 participants planned
- Regional One Health, Memphis, Tennessee
Phase 2PsilocybinNCT06786325
Wellcome Leap Psilocybin for OUD
- Conditions:
- Opioid Use Disorder
- Sponsor:
- Anna Rose Childress, Ph.D.
- Who:
- ages 18 Years to 60 Years, 36 participants planned
- University of Pennsylvania, Philadelphia, Pennsylvania
Phase 2PsilocybinNCT06810310
Psilocybin on Brain Mechanisms of Motivation in OUD
- Conditions:
- Opioid Use Disorder
- Sponsor:
- University of Pennsylvania
- Who:
- ages 18 Years to 60 Years, 24 participants planned
- University of Pennsylvania, Philadelphia, Pennsylvania
Phase 2Ketamine / esketamineNCT06943859
Ketamine for Opioid Use Disorder
- Conditions:
- Opioid Use Disorder
- Sponsor:
- University of Maryland, Baltimore
- Who:
- ages 18 Years to 65 Years, 50 participants planned
- University of Maryland Addiction Programs and Affiliated Clinics, Baltimore, Maryland
Trials outside the United States
Phase 2PsilocybinNCT05585229
Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication
- Conditions:
- Opioid Dependence; Chronic Pain
- Sponsor:
- University of British Columbia
- Who:
- ages 19 Years to 75 Years, 10 participants planned
- Where:
- Canada
Phase 4Ketamine / esketamineNCT06774274
Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.
- Conditions:
- Pain, Postoperative; Opioid Use; Major Surgery
- Sponsor:
- Universidad de Antioquia
- Who:
- ages 18 Years and over, 120 participants planned, accepts healthy volunteers
- Where:
- Colombia
Early phase 1Ketamine / esketamineNCT07408193
The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.
- Conditions:
- Opioid-Refractory Chronic Cancer-Related Pain
- Sponsor:
- National and Kapodistrian University of Athens
- Who:
- ages 18 Years and over, 24 participants planned
- Where:
- Greece