Clinical trials / Texas
Psychedelic and ketamine trials recruiting in Texas
11 trials registered on ClinicalTrials.gov were recruiting at one or more sites in Texas on 26 Oct 2026. By substance: Ketamine / esketamine 6, Psilocybin 5. By condition: depression 9, ptsd 3, opioid use disorder 1, anxiety 2, cancer and end-of-life distress 2, bipolar disorder 1.
From the ClinicalTrials.gov registry (US National Library of Medicine), read through its public API on 26 Oct 2026: studies marked as recruiting whose interventions name the substance. Titles, sponsors, phases, conditions and sites are the registry's own entries, written by the sponsors. We have not vetted any trial, and recruiting status changes; the registry record and the study team have the current eligibility rules.
Phase 3Ketamine / esketamineNCT07227454
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder (AVENUE)
- Conditions:
- Depressive Disorder, Major
- Sponsor:
- Janssen Research & Development, LLC
- Who:
- ages 12 Years to 17 Years, 258 participants planned
- Also in:
- Brazil, Hungary, Italy, Romania, Spain, Taiwan
- John S Dunn Behavioral Sciences Center at UTHealth Houston, Houston, Texas
Phase 3Ketamine / esketamineNCT06713616
PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
- Conditions:
- Depression
- Sponsor:
- Yale University
- Who:
- ages 18 Years and over, 400 participants planned
- Houston Center for Advanced Psychiatric Treatment, Bellaire, Texas
ObservationalKetamine / esketamineNCT06725277
The OBSERVE Protocol
- Conditions:
- Major Depression Disorder
- Sponsor:
- Yale University
- Who:
- 450 participants planned
- Houston Center for Advanced Psychiatric Treatment, Bellaire, Texas
Phase 1Ketamine / esketamineNCT06480201
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
- Conditions:
- Healthy; Major Depressive Disorder; Treatment Resistant Depression
- Sponsor:
- Texas A&M University
- Who:
- ages 21 Years to 45 Years, 100 participants planned, accepts healthy volunteers
- Wells Medicine, Houston, Texas
- Texas A&M (Houston Methodist Hospital Location), Houston, Texas
Phase 4Ketamine / esketamineNCT06903819
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
- Conditions:
- Orthopedic Trauma Surgery Patients; Postoperative Pain; Opioid Use; Depression; Post-traumatic Stress Disorder (PTSD)
- Sponsor:
- Texas Tech University Health Sciences Center
- Who:
- ages 18 Years to 65 Years, 90 participants planned
- Texas Tech University Health Sciences Center Lubbock, Lubbock, Texas
- University Medical Center, Lubbock, Texas
Phase 2PsilocybinNCT06132178
Psilocybin rTMS for Treatment Resistant Depression (PSILOBSD)
- Conditions:
- Treatment Resistant Depression; MDD; Major Depressive Disorder; Recurrent Depression; Depression
- Sponsor:
- University of Texas at Austin
- Who:
- ages 22 Years to 65 Years, 100 participants planned
- Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin, Texas
Phase 2PsilocybinNCT06200155
Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy
- Conditions:
- Depression, Anxiety; Psilocybin-Assisted Psychotherapy; Advanced Cancer
- Sponsor:
- M.D. Anderson Cancer Center
- Who:
- ages 25 Years and over, 48 participants planned
- MD Anderson Cancer Center, Houston, Texas
Phase 4Ketamine / esketamineNCT06414356
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
- Conditions:
- Neuropathic Pain; PTSD
- Sponsor:
- Margaux M. Salas, PhD
- Who:
- ages 18 Years to 70 Years, 30 participants planned, accepts healthy volunteers
- Brooke Army Medical Center, San Antonio, Texas
Phase 2PsilocybinNCT06706232
Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality
- Conditions:
- Bipolar II Disorder; Depression, Bipolar; Suicidality
- Sponsor:
- The University of Texas Health Science Center, Houston
- Who:
- ages 25 Years to 70 Years, 10 participants planned
- The University of Texas Health Science Center at Houston, Houston, Texas
Phase 2PsilocybinNCT06801041
TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors
- Conditions:
- Depression; Anxiety; Cancer
- Sponsor:
- M.D. Anderson Cancer Center
- Who:
- ages 18 Years and over, 20 participants planned
- The University of Texas M. D. Anderson Cancer Center, Houston, Texas
Phase 2PsilocybinNCT06888128
State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma (STARLIGHT)
- Conditions:
- PTSD
- Sponsor:
- Baylor College of Medicine
- Who:
- ages 21 Years to 64 Years, 15 participants planned
- Baylor College of Medicine, Houston, Texas