Classic psychedelic
Banisteriopsis caapi + Psychotria viridis
Central to indigenous Amazonian shamanism for over 1,000 years. Used for healing, divination, and spiritual guidance.
At a glance
Reported effects
Legal status
DMT is controlled, but religious exemptions exist in some countries for church use.
Research
Growing clinical research for depression, PTSD, and addiction treatment.
Palhano-Fontes F, et al. · Psychological Medicine · 2019
Placebo-controlled trial in 29 people with treatment-resistant depression: one ayahuasca dose cut depression scores within a week.
What the study foundDos Santos RG, et al. · Revista Brasileira de Psiquiatria · 2016
Systematic review of 21 animal and human studies found early, mostly uncontrolled evidence that ayahuasca may ease anxiety and depression.
What the study foundFrecska E, et al. · Frontiers in Pharmacology · 2016
Narrative review of ayahuasca's therapeutic potential, proposing a sigma-1 receptor anti-inflammatory mechanism alongside its serotonergic effects.
What the study foundSanches RF, et al. · Journal of Clinical Psychopharmacology · 2016
Open-label study of 17 inpatients with recurrent depression found one ayahuasca dose lowered depression scores for 21 days and changed brain blood flow.
What the study foundFeatured partner
Rythmia, in Costa Rica, is a Peyote.com partner offering ayahuasca.
The dispatch
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