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All substances

Classic psychedelic

Mescaline

3,4,5-trimethoxyphenethylamine

Sacred to Native American tribes for over 5,000 years. Used in religious ceremonies and healing rituals.

At a glance

Onset
1-3 hours
Duration
10-14 hours
Origin
Natural - found in peyote, San Pedro, and other cacti

Reported effects

  • Visual hallucinations
  • Enhanced color perception
  • Spiritual insights
  • Emotional openness
  • Body awareness
  • Connection to nature

Legal status

Controlled substance, but peyote use protected for registered Native American Church members in US.

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Research

Limited modern research, but historical studies show therapeutic potential.

Mescaline and the Native American Church: therapeutic implications

Halpern JH, Sherwood AR, Hudson JI, et al. · Journal of Psychoactive Drugs · 2005

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