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Classic psychedelic

San Pedro (Huachuma)

Echinopsis pachanoi

One of the oldest psychoactive plants in the Americas with archaeological evidence from Chavin de Huantar dating to 1300 BCE. Used by Andean curanderos in mesa ceremonies. The colonial Spanish named it 'San Pedro' (Saint Peter) as the key that opens the gates of heaven.

A tall clump of columnar San Pedro cactus on a dry Andean hillside beside a stone path
San Pedro, Echinopsis pachanoi, on a hillside in Peru. Photo: Annika Lindqvist, CC BY 4.0, via Wikimedia Commons.

At a glance

Onset
1-2 hours
Duration
10-14 hours
Origin
Natural - large columnar cactus native to the Andes Mountains of Peru and Ecuador

Cultivated plants only

The Andean curanderos who work with San Pedro have asked people to stop using wild plants, so we point only to cultivated San Pedro.

Reported effects

  • warm euphoria
  • heart-opening experiences
  • connection with nature
  • gentle visual effects
  • emotional healing
  • spiritual insight
  • increased empathy

Legal status

Mescaline is Schedule I in the US, but San Pedro cactus is legal to grow as ornamental plant in most countries. Legal and culturally integrated in Peru, Bolivia, Ecuador.

Check status by country →

Research

Limited formal clinical research. 2021 survey by Agin-Liebes et al. found mescaline users reported lasting improvements in depression, anxiety, and PTSD. Heffter Research Institute has expressed interest.

The dispatch

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