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Salvia

Salvia divinorum (active: salvinorin A)

Used by Mazatec shamans for divination and healing. Maria Sabina introduced it to the Western world.

Broad green leaves of Salvia divinorum growing beside a forest stream — Salvia divinorum growing wild in Mexico. Photo: Alan Rockefeller, CC BY 4.0, via Wikimedia Commons.

At a glance

Onset: 30 seconds to 2 minutes
Duration: 5-30 minutes
Origin: Natural plant native to Oaxaca, Mexico

Reported effects

Intense but brief hallucinations
Out-of-body experiences
Reality dissolution
Uncontrollable laughter or fear
Amnesia of the experience

Legal status

Legal in many places but banned in others. Age restrictions common.

Check status by country →

Research

Limited research due to short duration and intensity of effects.

Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A

Cunningham CW, et al. · Pharmacological Reviews · 2011

Review of how salvinorin A, from Salvia divinorum, acts on kappa-opioid receptors and where it might have medical uses.

What the study found

The dispatch

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