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Harmala Alkaloids

Harmine, Harmaline, Tetrahydroharmine

Essential component of ayahuasca, used to enable oral DMT activity in Amazonian ceremonies

A low, finely leaved Syrian rue plant on bare earth
Syrian rue, Peganum harmala, the main natural source of harmala alkaloids, in its native range in Syria. Photo: Anas A. Emad, CC BY-SA 4.0, via Wikimedia Commons.

At a glance

Onset
30-60 minutes
Duration
3-6 hours
Origin
Banisteriopsis caapi (Ayahuasca), Peganum harmala (Syrian Rue)

Reported effects

  • DMT potentiation
  • Light euphoria
  • Dream enhancement
  • Mild sedation
  • Enhanced meditation

Legal status

Legal in most countries

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Research

Research into neuroprotective effects and antidepressant properties

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